🎉 $25 OFF your evaluation — Use code 25OFF at checkout
Nerolidol
Trans-Nerolidol
Pronounced: neh-ROL-ih-dol
Nerolidol is a sesquiterpene terpene with a woody, floral, with notes of citrus, apple, and rose aroma. It's also found naturally in Neroli (orange blossom), Jasmine, Tea tree. Research suggests nerolidol research suggests calming and sedative properties, though more human studies are needed.
Boiling Point
252°F (122°C)
Aroma
Woody
Also Found In
Aroma Profile:
Woody, floral, with notes of citrus, apple, and rose
What is Nerolidol?
Trans-nerolidol is a secondary sesquiterpene found in many aromatic plants and certain cannabis strains. It's a key component of neroli (orange blossom) oil and contributes woody, floral notes to cannabis profiles. Nerolidol is being studied for its sedative properties, antibiotic-enhancing effects, and ability to improve transdermal drug delivery.
How Nerolidol Works
Nerolidol demonstrates sedative and anxiolytic effects through mechanisms that don't impair motor coordination, suggesting a different pathway than traditional sedatives. It also shows remarkable ability to enhance skin penetration of other compounds, making it valuable in transdermal applications. Its antimicrobial effects appear to work by disrupting bacterial cell membranes.
Researched Effects
Sedative & Anxiolytic
Moderate EvidenceAnimal studies show anti-anxiety effects without motor impairment, plus sedative and antioxidant activity.
✓ Compliant Language
Research suggests calming and sedative properties
✗ Avoid Saying
Treats anxiety or is a sleep aid
Sources
Antibiotic Synergy
Moderate EvidenceSensitizes bacteria to antibiotics by disrupting cell membranes, enhancing drug efficacy.
✓ Compliant Language
Shows ability to enhance antibiotic effectiveness in lab studies
✗ Avoid Saying
Treats infections or replaces antibiotics
Skin Penetration Enhancement
Moderate EvidenceSignificantly enhances transdermal delivery of drugs through the skin.
✓ Compliant Language
May improve absorption of topical compounds
✗ Avoid Saying
Increases drug absorption
Antimalarial
Emerging ResearchEnhanced efficacy of antimalarial drugs in combination studies.
✓ Compliant Language
Being researched for antimalarial applications
✗ Avoid Saying
Treats malaria
Sources
Understanding Evidence Levels
Safety Information
Trans-nerolidol is generally well-tolerated and is used in perfumery and cosmetics. It appears in trace to low amounts in cannabis and is considered safe at typical exposure levels.
Scientific References
Goel R, et al. • Indian Journal of Pharmacology (2016)
PubMed ID: 27756946
Demonstrated anti-anxiety effects in mice without impairing motor coordination.
Brehm-Stecher BF, Johnson EA. • Antimicrobial Agents and Chemotherapy (2003)
PubMed ID: 12936978
Found nerolidol disrupts bacterial membranes, enhancing antibiotic efficacy against S. aureus and E. coli.
Saito AY, et al. • International Journal of Antimicrobial Agents (2007)
PubMed ID: 17174049
Enhanced efficacy of antimalarial drugs when used in combination.
Frequently Asked Questions
What is nerolidol?
Trans-nerolidol is a sesquiterpene with a woody, floral aroma featuring notes of citrus and rose. It's found in neroli (orange blossom), jasmine, and certain cannabis strains like Island Sweet Skunk and Jack Herer.
What are nerolidol's effects?
Research shows nerolidol has sedative and anti-anxiety properties without motor impairment. It also enhances skin penetration of other compounds and may boost antibiotic effectiveness.
Which cannabis strains contain nerolidol?
Nerolidol is found in strains like Island Sweet Skunk, Jack Herer, and Skywalker OG, though typically in trace to low amounts as a secondary terpene.
Quick Facts
- Full Name
- Trans-Nerolidol
- Category
- sesquiterpene
- Boiling Point
- 252°F (122°C)
- Aroma
- Woody, floral, with notes of citrus, apple, and rose
Looking for strains high in Nerolidol? Our doctors can help you find the right product.
Find a DoctorRelated Terpenes
Educational Information
This content is for educational purposes only and is not medical advice. Consult a healthcare provider before using cannabis products.
Strain Variability
Terpene profiles vary significantly between batches, growers, and growing conditions—even for the same strain name. Always check lab test results.
Indica/Sativa Note
The indica/sativa distinction is largely marketing. Effects are better predicted by cannabinoid and terpene profiles than strain classification.