Trainwreck | Cannabis Strain Review & Effects
Mexican x Thai x Afghani
Trainwreck is a hybrid strain (Mexican x Thai x Afghani) with THC levels of 18-25%. It features a Terpinolene-dominant terpene profile and is known for euphoric and uplifted. Best used during the afternoon.
THC
18-25%
CBD
0-1%
Best Time
Primary Effects
Flavor Notes
Pine, Lemon, Earthy, Spicy
Aroma
Pine aroma with earthy and lemon notes
Research Sources
26 peer-reviewed studies
Verified Via
PubMed / DOI
Evidence
Research-Backed
Updated
December 2025
What is Trainwreck?
Trainwreck is a hybrid strain (Mexican x Thai x Afghani) with THC levels of 18-25%. It features a Terpinolene-dominant terpene profile and is known for euphoric and uplifted. Best used during the afternoon.
About Trainwreck Strain
Trainwreck is a balanced hybrid cannabis strain created by crossing Mexican x Thai x Afghani, bred by Unknown (NorCal). With THC levels ranging from 18% to 25%, Trainwreck is considered a high-potency strain that delivers powerful effects.
Users of Trainwreck commonly report feeling euphoric, uplifted, creative, happy. The effects provide a balanced experience, starting with gentle mental stimulation before transitioning into full-body relaxation. This makes Trainwreck versatile for various situations and times of day. The balanced nature of this strain makes it well-suited for afternoon use when you want relaxation without excessive sedation.
Medical cannabis patients frequently turn to Trainwreck for relief from chronic pain, ptsd, migraines, anxiety. Terpinolene's presence adds uplifting qualities while potentially offering antioxidant and sedative properties at higher doses.
Due to its high potency, Trainwreck is best suited for experienced cannabis consumers. New users should approach with caution, starting with a very small dose and waiting to assess effects before consuming more. Common side effects may include dry mouth, paranoia, anxiety. Staying well-hydrated and having snacks on hand can help minimize discomfort.
The aroma of Trainwreck is characterized by pine, earthy, lemon notes that create a distinctive sensory profile. On the palate, expect pine, lemon, earthy flavors that develop throughout each session. The terpinolene-dominant terpene profile is largely responsible for these aromatic and flavor characteristics, contributing to the entourage effect that shapes the overall experience.
Related Reading
Commonly Used For
Patients often seek Trainwreck for relief from the following conditions:
Note: These are commonly reported uses based on patient experiences. Individual results may vary. Always consult with a healthcare provider to determine if medical cannabis is appropriate for your specific condition.
Potential Side Effects
Be aware of these commonly reported side effects when using Trainwreck:
How to minimize side effects
- Start with a low dose, especially if new to cannabis
- Stay hydrated before, during, and after use
- Use in a comfortable, familiar environment
- Avoid mixing with alcohol or other substances
Terpene Profile
Primary research: Sedative (in isolation)
Concentration Levels
Cannabinoid Profile
Therapeutic Profile Matches
Based on Trainwreck's terpene and cannabinoid profile, it may be well-suited for these therapeutic applications:
migraines
- High myrcene content supports migraines & headaches
- thc dominant ratio matches profile
- Best used afternoon, aligning with condition needs
Match scores are theoretical
These scores are based on terpene/cannabinoid research and do not guarantee specific effects. Individual responses vary significantly. Always consult a healthcare provider.
- 1
Ito K, Ito M. The sedative effect of inhaled terpinolene in mice and its structure-activity relationships Journal of Natural Medicines. 2013
Terpinolene prolonged sleep time in mice.
- 2
Grassmann J, et al. The monoterpene terpinolene from the oil of Pinus mugo L. in concert with alpha-tocopherol and beta-carotene effectively prevents oxidation of LDL Phytomedicine. 2005
Terpinolene showed strong antioxidant activity.
- 3
Surendran S, et al. Myrcene-What Are the Potential Health Benefits of This Flavouring and Aroma Agent? Frontiers in Nutrition. 2021
Comprehensive review: β-myrcene may potentiate the anti-nociceptive properties of cannabinoids.
- 4
Johnson MB, et al. The Effects of β-myrcene on Simulated Driving and Divided Attention: A Double-Blind, Placebo-Controlled, Crossover Pilot Study Cannabis. 2023
Found myrcene alone did not significantly impair simulated driving performance.
- 5
do Vale TG, et al. Central effects of citral, myrcene and limonene, constituents of essential oil chemotypes from Lippia alba (Mill.) n.e. Brown Phytomedicine. 2002
Demonstrated dose-dependent sedative and motor-relaxant effects of myrcene in mice.
- 6
Lorenzetti BB, et al. Myrcene mimics the peripheral analgesic activity of lemongrass tea Journal of Ethnopharmacology. 1991
Found peripheral analgesic activity in animal models.
- 7
Liktor-Busa E, et al. Analgesic Potential of Terpenes Derived from Cannabis sativa Pharmacological Reviews. 2021
Comprehensive review of cannabis terpene analgesic effects including myrcene.
- 8
Perry NS, et al. In-vitro inhibition of human erythrocyte acetylcholinesterase by salvia lavandulaefolia essential oil and constituent terpenes Journal of Pharmacy and Pharmacology. 2000
Pinene and other terpenes inhibit AChE with memory implications.
- 9
Ding Y, et al. Eucalyptol, limonene and pinene enteric capsules attenuate airway inflammation and obstruction in lipopolysaccharide-induced chronic bronchitis rat model via TLR4 signaling inhibition Phytomedicine. 2024
Pinene attenuates airway inflammation and obstruction.
- 10
Nam SY, et al. The therapeutic efficacy of α-pinene in an experimental mouse model of allergic rhinitis International Immunopharmacology. 2014
α-Pinene reduced IgE-mediated allergic inflammation.
- 11
Salehi B, et al. Therapeutic Potential of α- and β-Pinene: A Miracle Gift of Nature Biomolecules. 2019
Most comprehensive review of pinene pharmacology.
- 12
Gaoni Y, Mechoulam R. Isolation, structure, and partial synthesis of an active constituent of hashish Journal of the American Chemical Society. 1964. doi:10.1021/ja01062a046
Landmark paper first identifying and synthesizing THC.
- 13
Whiting PF, et al. Cannabinoids for medical use: A systematic review and meta-analysis JAMA. 2015
Comprehensive review finding moderate evidence for chronic pain.
- 14
Aviram J, Samuelly-Leichtag G. Efficacy of Cannabis-Based Medicines for Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Pain Physician. 2017
Systematic review of clinical trials for neuropathic pain.
- 15
Lutge EE, et al. The medical use of cannabis for reducing morbidity and mortality in patients with HIV/AIDS Cochrane Database of Systematic Reviews. 2013
Systematic review of cannabis for HIV/AIDS symptoms including appetite.
- 16
Smith LA, et al. Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy Cochrane Database of Systematic Reviews. 2015
High-quality evidence for CINV efficacy.
- 17
Kesner AJ, Lovinger DM. Cannabinoids, Endocannabinoids and Sleep Frontiers in Molecular Neuroscience. 2020
Review of THC effects on sleep architecture.
- 18
Novotna A, et al. A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols (Sativex), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis European Journal of Neurology. 2011
Phase III trial showing efficacy for MS spasticity.
- 19
Silvestro S, et al. Molecular Targets of Cannabidiol in Experimental Models of Neurological Disease Molecules. 2020
Comprehensive review of CBD's therapeutic applications and molecular targets.
- 20
Thiele EA, et al. Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial Lancet. 2018
Phase III trial leading to FDA approval of Epidiolex.
- 21
Devinsky O, et al. Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial Lancet Neurology. 2016
Open-label trial showing 36.5% reduction in seizures.
- 22
Shannon S, et al. Cannabidiol in anxiety and sleep: A large case series Permanente Journal. 2019
79.2% of patients reported reduced anxiety within first month.
- 23
Bergamaschi MM, et al. Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients Neuropsychopharmacology. 2011
CBD reduced anxiety in simulated public speaking test.
- 24
Burstein S. Cannabidiol (CBD) and its analogs: a review of their effects on inflammation Bioorganic & Medicinal Chemistry. 2015
Review of CBD's anti-inflammatory mechanisms.
- 25
Shannon S, et al. Cannabidiol in Anxiety and Sleep: A Large Case Series Permanente Journal. 2019
66.7% of patients reported improved sleep in this anxiety and sleep study.
- 26
Urits I, et al. Use of cannabidiol (CBD) for the treatment of chronic pain Best Practice & Research Clinical Anaesthesiology. 2020
Comprehensive review of CBD for chronic pain management.
Research Verification
All citations link directly to PubMed or the original source. You can verify any claim by clicking the reference link. Learn more about how we research.
Frequently Asked Questions
What are the effects of Trainwreck?
Trainwreck is known for producing euphoric, uplifted, creative, happy effects. As a hybrid, it's typically best suited for afternoon use.
What conditions might Trainwreck help with?
Trainwreck is commonly used by patients seeking relief from chronic pain, ptsd, migraines, anxiety. Always consult with a healthcare provider before using cannabis for medical purposes.
How strong is Trainwreck?
Trainwreck is considered a high-potency strain with THC levels typically ranging from 18-25%. New users should approach with caution and start with a low dose.
What does Trainwreck taste and smell like?
Trainwreck features pine, lemon, earthy flavors with a pine, earthy, lemon aroma. Its unique terpene combination creates a memorable sensory experience.
What are the side effects of Trainwreck?
Common side effects include dry mouth, paranoia, anxiety. Staying hydrated and starting with a low dose can help minimize these effects.
Quick Facts
- Type
- Hybrid
- Genetics
- Mexican x Thai x Afghani
- Breeder
- Unknown (NorCal)
- Best Time of Use
- Afternoon
- Availability
- moderate
- Grow Difficulty
- moderate
- Experience Level
- Experienced Users
Dominant Terpene
Terpinolene
Fresh, piney, floral, with citrus and herbal notes
Want to try Trainwreck? Get your medical marijuana card today.
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Educational Information
This content is for educational purposes only and is not medical advice. Consult a healthcare provider before using cannabis products.
Strain Variability
Profiles vary between batches, growers, and growing conditions. Always check lab test results for the specific product you're purchasing.
Beyond Indica/Sativa
Effects are better predicted by cannabinoid and terpene profiles than strain classification. Focus on the chemistry, not the label.
Understanding Therapeutic Profiles
Learn how terpenes and cannabinoids work together to create each strain's unique effects and therapeutic potential through the entourage effect.
Learn About Therapeutic Profiles