MMJ.com
Hybrid
Beginner Friendly

Lemon Skunk | Cannabis Strain Review & Effects

Skunk #1 pheno x Skunk #1 pheno

Lemon Skunk is a hybrid strain (Skunk #1 pheno x Skunk #1 pheno) with THC levels of 15-22%. It features a Limonene-dominant terpene profile and is known for uplifted and happy. Best used during the afternoon.

THC

15-22%

CBD

0-1%

Best Time

Afternoon

Primary Effects

UpliftedHappyEnergeticCreativeEuphoric

Flavor Notes

Lemon, Skunk, Citrus, Earthy

Aroma

Lemon aroma with skunk and citrus notes

Research Sources

29 peer-reviewed studies

Verified Via

PubMed / DOI

Evidence

Research-Backed

Updated

December 2025

Every claim cites peer-reviewed research
How We Research

What is Lemon Skunk?

Lemon Skunk is a hybrid strain (Skunk #1 pheno x Skunk #1 pheno) with THC levels of 15-22%. It features a Limonene-dominant terpene profile and is known for uplifted and happy. Best used during the afternoon.

About Lemon Skunk Strain

Lemon Skunk is a balanced hybrid cannabis strain created by crossing Skunk #1 pheno x Skunk #1 pheno, bred by DNA Genetics. Testing at 15-22% THC, Lemon Skunk offers moderate to strong potency suitable for regular cannabis consumers.

Users of Lemon Skunk commonly report feeling uplifted, happy, energetic, creative. The effects provide a balanced experience, starting with gentle mental stimulation before transitioning into full-body relaxation. This makes Lemon Skunk versatile for various situations and times of day. The balanced nature of this strain makes it well-suited for afternoon use when you want relaxation without excessive sedation.

Medical cannabis patients frequently turn to Lemon Skunk for relief from depression, stress, fatigue, appetite loss. The limonene-dominant profile may offer mood-enhancing and stress-relieving benefits, making it popular among patients managing anxiety or depression.

Lemon Skunk is considered beginner-friendly, making it accessible for those new to cannabis or with lower tolerance levels. Start with a small dose and wait at least 15-30 minutes before consuming more, especially when trying this strain for the first time. Common side effects may include dry mouth, dry eyes. Staying well-hydrated and having snacks on hand can help minimize discomfort.

The aroma of Lemon Skunk is characterized by lemon, skunk, citrus notes that create a distinctive sensory profile. On the palate, expect lemon, skunk, citrus flavors that develop throughout each session. The limonene-dominant terpene profile is largely responsible for these aromatic and flavor characteristics, contributing to the entourage effect that shapes the overall experience.

Related Reading

Understanding Limonene

Learn about this terpene

Browse All Strains

Compare Hybrid strains

Cannabis for Depression

Qualifying conditions guide

Get Your MMJ Card

Access medical cannabis legally

Commonly Used For

Patients often seek Lemon Skunk for relief from the following conditions:

DepressionStressFatigueAppetite Loss

Note: These are commonly reported uses based on patient experiences. Individual results may vary. Always consult with a healthcare provider to determine if medical cannabis is appropriate for your specific condition.

Potential Side Effects

Be aware of these commonly reported side effects when using Lemon Skunk:

Dry MouthDry Eyes

How to minimize side effects

  • Start with a low dose, especially if new to cannabis
  • Stay hydrated before, during, and after use
  • Use in a comfortable, familiar environment
  • Avoid mixing with alcohol or other substances

Terpene Profile

Limonenedominant
Citrus, lemon, orange~0.8%

Primary research: THC Anxiety Reduction

Myrceneprimary
Earthy, musky, clove-like~0.4%

Primary research: Sedation & Relaxation

Beta-Caryophyllenesecondary
Spicy, peppery, woody, clove-like~0.2%

Primary research: Anti-inflammatory

Concentration Levels

Dominant (>1.0%)
Primary (0.5-1.0%)
Secondary (0.1-0.5%)
Trace (<0.1%)

Cannabinoid Profile

THCPsychoactive

15-22%

Pain Relief

CBD

0-1%

Seizure Reduction

Therapeutic Profile Matches

Based on Lemon Skunk's terpene and cannabinoid profile, it may be well-suited for these therapeutic applications:

nausea

67%
Good Match
  • High limonene content supports nausea & appetite loss
  • thc dominant ratio matches profile
  • High beta-caryophyllene content supports nausea & appetite loss

migraines

66%
Good Match
  • High myrcene content supports migraines & headaches
  • thc dominant ratio matches profile
  • Best used afternoon, aligning with condition needs

anxiety

61%
Moderate Match
  • High limonene content supports anxiety
  • High beta-caryophyllene content supports anxiety
  • Best used afternoon, aligning with condition needs

depression

55%
Moderate Match
  • High limonene content supports depression
  • Best used afternoon, aligning with condition needs

epilepsy

55%
Moderate Match
  • High beta-caryophyllene content supports epilepsy & seizures
  • Best used afternoon, aligning with condition needs

Match scores are theoretical

These scores are based on terpene/cannabinoid research and do not guarantee specific effects. Individual responses vary significantly. Always consult a healthcare provider.

  1. 1

    Tagen M, et al. D-Limonene Reduces THC-induced Anxiety via Adenosine A2A Receptor Mechanisms Psychopharmacology. 2024

    Johns Hopkins study showing limonene specifically reduces THC-induced anxiety in humans.

    PubMed: 38127108View Source
  2. 2

    Vieira AJ, et al. Limonene: Aroma of innovation in health and disease Chemico-Biological Interactions. 2018

    Comprehensive review of limonene's anxiolytic and antidepressant effects.

    PubMed: 29522718View Source
  3. 3

    Kiecolt-Glaser JK, et al. Olfactory influences on mood and cognition from citrus fragrance Psychoneuroendocrinology. 2008

    Lemon scent exposure improved mood and reduced norepinephrine.

    PubMed: 18178322View Source
  4. 4

    Sun J. D-Limonene for heartburn and GERD Alternative Medicine Review. 2007

    D-limonene showed gastroprotective effects.

    PubMed: 17472505View Source
  5. 5

    Surendran S, et al. Myrcene—What Are the Potential Health Benefits of This Flavouring and Aroma Agent? Frontiers in Nutrition. 2021

    Comprehensive review: β-myrcene may potentiate the anti-nociceptive properties of cannabinoids.

    PubMed: 34368215View Source
  6. 6

    Sewell RA, et al. The Effects of β-myrcene on Simulated Driving Cannabis and Cannabinoid Research. 2023

    Found myrcene alone did not significantly impair simulated driving performance.

    PubMed: 37126442View Source
  7. 7

    do Vale TG, et al. Sedative effects of myrcene in mice Phytomedicine. 2002

    Demonstrated dose-dependent sedative and motor-relaxant effects in mice.

    PubMed: 12587690View Source
  8. 8

    Lorenzetti BB, et al. Anti-inflammatory activity of myrcene Journal of Ethnopharmacology. 1991

    Found peripheral analgesic activity in animal models.

    PubMed: 1753786View Source
  9. 9

    Rao VS, et al. Antinociceptive action of myrcene Journal of Pharmacy and Pharmacology. 1990

    Investigated pain-modulating mechanisms in animal studies.

    PubMed: 1983142View Source
  10. 10

    Gertsch J, et al. β-Caryophyllene is a dietary cannabinoid Proceedings of the National Academy of Sciences. 2008

    Landmark paper: BCP directly activates CB2 receptors.

    PubMed: 18574142View Source
  11. 11

    Klauke AL, et al. β-Caryophyllene reduces neuropathic pain via CB2 and PPAR-γ European Journal of Pain. 2014

    Showed dual mechanism for neuropathic pain relief.

    PubMed: 24338862View Source
  12. 12

    Bahi A, et al. Anxiolytic-like effect of β-caryophyllene Physiology & Behavior. 2014

    BCP reduced anxiety via CB2 receptor activation.

    PubMed: 24582908View Source
  13. 13

    Horvath B, et al. Anti-inflammatory effects of β-caryophyllene Free Radical Biology and Medicine. 2012

    BCP reduced inflammation markers and oxidative stress.

    PubMed: 22569421View Source
  14. 14

    Tambe Y, et al. Gastroprotective effects of β-caryophyllene Planta Medica. 1996

    BCP protected gastric mucosa in ulcer models.

    PubMed: 8923806View Source
  15. 15

    Gaoni Y, Mechoulam R. Isolation, structure, and partial synthesis of an active constituent of hashish Journal of the American Chemical Society. 1964. doi:10.1021/ja01062a046

    Landmark paper first identifying and synthesizing THC.

    DOIView Source
  16. 16

    Whiting PF, et al. Cannabinoids for medical use: A systematic review and meta-analysis JAMA. 2015

    Comprehensive review finding moderate evidence for chronic pain.

    PubMed: 26103030View Source
  17. 17

    Aviram J, Samuelly-Leichtag G. Cannabinoids for neuropathic pain Journal of Pain Research. 2017

    Review of clinical trials for neuropathic pain.

    PubMed: 28860855View Source
  18. 18

    Lutge EE, et al. Dronabinol for AIDS-related anorexia Cochrane Database of Systematic Reviews. 2013

    Systematic review of appetite stimulation evidence.

    PubMed: 23539665View Source
  19. 19

    Smith LA, et al. Cannabinoids for chemotherapy-induced nausea and vomiting Cochrane Database of Systematic Reviews. 2015

    High-quality evidence for CINV efficacy.

    PubMed: 26561338View Source
  20. 20

    Kesner AJ, Lovinger DM. Cannabis, cannabinoids, and sleep Neuropsychopharmacology. 2020

    Review of THC effects on sleep architecture.

    PubMed: 31767987View Source
  21. 21

    Novotna A, et al. Nabiximols for spasticity in multiple sclerosis European Journal of Neurology. 2011

    Phase III trial showing efficacy for MS spasticity.

    PubMed: 21696543View Source
  22. 22

    Silvestro S, et al. Therapeutic potential of cannabidiol (CBD) Journal of Cellular Physiology. 2020

    Comprehensive review of CBD's therapeutic applications.

    PubMed: 31960376View Source
  23. 23

    Devinsky O, et al. Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome New England Journal of Medicine. 2018

    Phase III trial leading to FDA approval of Epidiolex.

    PubMed: 29768152View Source
  24. 24

    Devinsky O, et al. Cannabidiol for treatment-resistant epilepsy Lancet Neurology. 2016

    Open-label trial showing 36.5% reduction in seizures.

    PubMed: 26724101View Source
  25. 25

    Shannon S, et al. Cannabidiol in anxiety and sleep: A large case series Permanente Journal. 2019

    79.2% of patients reported reduced anxiety within first month.

    PubMed: 30624194View Source
  26. 26

    Bergamaschi MM, et al. CBD reduces anxiety in social anxiety disorder Neuropsychopharmacology. 2011

    CBD reduced anxiety in simulated public speaking test.

    PubMed: 21307846View Source
  27. 27

    Burstein S. Cannabidiol as an emergent therapeutic strategy for reducing inflammation Bioorganic & Medicinal Chemistry. 2015

    Review of CBD's anti-inflammatory mechanisms.

    PubMed: 25997150View Source
  28. 28

    Shannon S, et al. Cannabidiol for treatment of insomnia Permanente Journal. 2019

    66.7% of patients reported improved sleep.

    PubMed: 30624194View Source
  29. 29

    Boyaji S, et al. Cannabidiol for chronic pain management Current Opinion in Anesthesiology. 2020

    Review of CBD's analgesic mechanisms.

    PubMed: 32740152View Source

Research Verification

All citations link directly to PubMed or the original source. You can verify any claim by clicking the reference link. Learn more about how we research.

Frequently Asked Questions

What are the effects of Lemon Skunk?

Lemon Skunk is known for producing uplifted, happy, energetic, creative effects. As a hybrid, it's typically best suited for afternoon use. This strain is considered beginner-friendly.

What conditions might Lemon Skunk help with?

Lemon Skunk is commonly used by patients seeking relief from depression, stress, fatigue, appetite loss. Always consult with a healthcare provider before using cannabis for medical purposes.

How strong is Lemon Skunk?

Lemon Skunk is considered moderately potent with THC levels typically ranging from 15-22%. Despite its potency, it's considered accessible for most users when dosed appropriately.

What does Lemon Skunk taste and smell like?

Lemon Skunk features lemon, skunk, citrus flavors with a lemon, skunk, citrus aroma. Its unique terpene combination creates a memorable sensory experience.

What are the side effects of Lemon Skunk?

Common side effects include dry mouth, dry eyes. Staying hydrated and starting with a low dose can help minimize these effects.

Quick Facts

Type
Hybrid
Genetics
Skunk #1 pheno x Skunk #1 pheno
Breeder
DNA Genetics
Genetic Family
Skunk Family
Best Time of Use
Afternoon
Availability
common
Grow Difficulty
moderate
Experience Level
Beginner Friendly

Dominant Terpene

Limonene

Citrus, lemon, orange

Want to try Lemon Skunk? Get your medical marijuana card today.

Get Your Card

Similar Strains

If you like Lemon Skunk, try these

Lemon HazeSuper Lemon HazeSour Diesel

Related by Genetics

Lemon Haze

hybrid sativa

Sour Diesel

hybrid sativa

Remedy

indica

Lavender

hybrid indica

Educational Information

This content is for educational purposes only and is not medical advice. Consult a healthcare provider before using cannabis products.

Strain Variability

Profiles vary between batches, growers, and growing conditions. Always check lab test results for the specific product you're purchasing.

Beyond Indica/Sativa

Effects are better predicted by cannabinoid and terpene profiles than strain classification. Focus on the chemistry, not the label.

Understanding Therapeutic Profiles

Learn how terpenes and cannabinoids work together to create each strain's unique effects and therapeutic potential through the entourage effect.

Learn About Therapeutic Profiles