CBN (Cannabinol) | Cannabinoid Guide
Complete Guide to CBN in Medical Cannabis
Pronounced: see-bee-EN
CBN (Cannabinol) is a psychoactive minor cannabinoid. Is CBN really the "sleep cannabinoid"? Learn the truth about cannabinol, how it forms from THC, and what research actually shows..
Boiling Point
365°F (185°C)
Formula
C₂₁H₂₆O₂
Legal Status
Legal federally when derived from hemp; minor psychoactive effects
May cause impairment. Do not drive or operate machinery after use.
Research Sources
3 peer-reviewed studies
Verified Via
PubMed / DOI
Evidence
Research-Backed
Updated
February 2026
What is CBN?
CBN (cannabinol) forms as THC ages and oxidizes, which is why older cannabis tends to have higher CBN levels. It's often marketed as "the sleep cannabinoid," though this reputation is largely anecdotal. Research suggests the sedative effects of aged cannabis may be due more to terpene profile changes (like increased myrcene) than CBN itself. CBN has mild psychoactive effects—roughly 10% the potency of THC.
How CBN Works
CBN binds weakly to CB1 receptors (about 10% of THC's affinity) and has moderate affinity for CB2 receptors. IMPORTANT: The sedative reputation of CBN is largely anecdotal. Scientific research suggests aged cannabis feels more sedating due to terpene profile changes rather than CBN itself. Russo (2011) notes this distinction in the entourage effect literature.
Researched Effects
Sedation
Emerging ResearchLimited research; reputation may be based on synergy with other compounds in aged cannabis.
✓ Compliant Language
Traditionally associated with relaxation and sleep
✗ Avoid Saying
Proven sleep aid
Sources
Appetite Stimulation
Emerging ResearchAnimal studies suggest appetite-stimulating effects.
✓ Compliant Language
May support healthy appetite
✗ Avoid Saying
Increases appetite
Sources
Antibacterial
Moderate EvidenceShows activity against antibiotic-resistant bacteria.
✓ Compliant Language
Demonstrates antibacterial properties in lab studies
✗ Avoid Saying
Treats infections
Sources
Medical Applications
Sleep Issues
Emerging ResearchMarketed for sleep; limited controlled human trials.
Dosing Guidance
Sleep products typically contain 2.5-5mg CBN, often combined with CBD and melatonin. Effects are milder than THC. May cause next-day grogginess at higher doses.
Safety Information
CBN has mild psychoactive effects and may cause drowsiness. Not recommended before driving or operating machinery. Limited long-term safety data available.
Potential Side Effects
- Drowsiness
- Mild psychoactive effects
- Dry mouth
- Next-day grogginess possible
Drug Interactions
Limited data. May enhance sedative effects of other substances. Use caution with sleep medications or alcohol.
Scientific References
3 peer-reviewed sources cited
- 1
Saleska JL, et al. A double-blind, randomized, placebo-controlled study of the safety and effects of CBN with and without CBD on sleep quality Journal of Cannabis Research. 2024
Randomized controlled trial showing CBN improves sleep quality.
- 2
Farrimond JA, et al. Cannabinol and cannabidiol exert opposing effects on rat feeding patterns Psychopharmacology. 2012
CBN stimulated appetite while CBD suppressed it.
- 3
Appendino G, et al. Antibacterial cannabinoids from Cannabis sativa: a structure-activity study Journal of Natural Products. 2008
CBN showed antibacterial activity against resistant bacteria.
Research Verification
All citations link directly to PubMed or the original source. You can verify any claim by clicking the reference link. Learn more about how we research.
Frequently Asked Questions
What is CBN?
CBN (cannabinol) is a mildly psychoactive cannabinoid that forms when THC ages and oxidizes. It's about 10% as potent as THC and is often marketed for sleep.
Does CBN help with sleep?
CBN is marketed as the "sleep cannabinoid," but evidence is limited. Its sedative reputation may come from aged cannabis, which contains CBN alongside other sedating compounds.
Is CBN psychoactive?
Mildly, yes. CBN has about 10% of THC's psychoactive potency. You may feel slight relaxation or drowsiness but not typical THC intoxication.
Quick Facts
- Full Name
- Cannabinol
- Category
- minor Cannabinoid
- Psychoactive
- Yes
- Boiling Point
- 365°F (185°C)
- Formula
- C₂₁H₂₆O₂
Want to explore CBN products? Get your medical marijuana card today.
Get Your CardRelated Cannabinoids
Medical Disclaimer
This content is for educational purposes only and is not medical advice. Consult a healthcare provider before using cannabis products.
Individual Variation
Cannabis affects everyone differently based on genetics, tolerance, and other factors. What works for one person may not work for another.
Start Low, Go Slow
Always begin with the lowest effective dose and increase gradually to minimize risk of adverse effects.