CBG (Cannabigerol) | Cannabinoid Guide
Complete Guide to CBG in Medical Cannabis
Pronounced: see-bee-JEE
CBG (Cannabigerol) is a non-psychoactive minor cannabinoid. Learn about CBG (cannabigerol), the precursor to all cannabinoids. Discover its unique properties, potential benefits, and emerging research..
Boiling Point
126°F (52°C)
Formula
C₂₁H₃₂O₂
Legal Status
Legal federally when derived from hemp; not scheduled
Research Sources
5 peer-reviewed studies
Verified Via
PubMed / DOI
Evidence
Research-Backed
Updated
February 2026
What is CBG?
CBG (cannabigerol) is often called the "mother of all cannabinoids" because it's the precursor from which all other cannabinoids are synthesized. While typically present in low concentrations (<1%) in mature cannabis, specialized CBG-dominant strains are now being cultivated for research and therapeutic applications.
How CBG Works
CBG interacts with both CB1 and CB2 receptors, though with lower affinity than THC. It also acts on alpha-2 adrenergic receptors (which may explain potential anti-inflammatory effects), 5-HT1A serotonin receptors, and TRPM8 channels involved in pain perception.
Researched Effects
Anti-inflammatory
Emerging ResearchPreclinical studies show promise for inflammatory bowel disease.
✓ Compliant Language
Early research suggests anti-inflammatory potential
✗ Avoid Saying
Treats IBD or inflammation
Sources
Neuroprotection
Emerging ResearchAnimal studies show potential protective effects on neural tissue.
✓ Compliant Language
Being researched for neuroprotective properties
✗ Avoid Saying
Protects the brain or treats neurological diseases
Sources
Antibacterial
Moderate EvidenceShows activity against antibiotic-resistant bacteria including MRSA.
✓ Compliant Language
Demonstrates antibacterial properties in lab studies
✗ Avoid Saying
Treats infections
Sources
Medical Applications
Inflammatory Bowel Disease
Emerging ResearchPreclinical studies show reduced inflammation in colitis models.
Glaucoma
Emerging ResearchMay reduce intraocular pressure; research ongoing.
Dosing Guidance
Limited human dosing data available. Most CBG products contain 10-50mg per serving. As a non-psychoactive cannabinoid, it's generally considered safe at moderate doses.
Safety Information
CBG appears to be well-tolerated in limited human studies. No significant adverse effects have been reported at typical doses. More research is needed on long-term safety.
Potential Side Effects
- Limited data available
- May cause drowsiness
- Dry mouth possible
- Appetite changes possible
Drug Interactions
Potential interactions not well-studied. May inhibit CYP450 enzymes similarly to CBD. Consult physician if taking other medications.
Scientific References
5 peer-reviewed sources cited
- 1
Nachnani R, et al. The Pharmacological Case for Cannabigerol Journal of Pharmacology and Experimental Therapeutics. 2021
Most comprehensive CBG pharmacology review to date.
- 2
Borrelli F, et al. Beneficial effect of cannabigerol on experimental inflammatory bowel disease Biochemical Pharmacology. 2013
CBG reduced colitis markers in mouse IBD models.
- 3
Valdeolivas S, et al. Neuroprotective properties of cannabigerol in Huntington's disease Neurotherapeutics. 2015
CBG improved motor deficits in HD mouse models.
- 4
Appendino G, et al. Antibacterial cannabinoids from Cannabis sativa Journal of Natural Products. 2008
CBG showed potent activity against MRSA.
- 5
Colasanti BK. A comparison of the ocular and central effects of delta 9-tetrahydrocannabinol and cannabigerol Journal of Ocular Pharmacology. 1990
CBG reduced intraocular pressure in cat models.
Research Verification
All citations link directly to PubMed or the original source. You can verify any claim by clicking the reference link. Learn more about how we research.
Frequently Asked Questions
What is CBG?
CBG (cannabigerol) is a non-psychoactive cannabinoid often called the "mother of all cannabinoids" because it's the precursor from which THC, CBD, and other cannabinoids are synthesized.
Does CBG get you high?
No. CBG is non-psychoactive and does not produce intoxication. It interacts with cannabinoid receptors differently than THC.
What is CBG used for?
CBG is being researched for potential anti-inflammatory, antibacterial, and neuroprotective properties. It's available in oils, capsules, and CBG-dominant hemp strains.
Quick Facts
- Full Name
- Cannabigerol
- Category
- minor Cannabinoid
- Psychoactive
- No
- Boiling Point
- 126°F (52°C)
- Formula
- C₂₁H₃₂O₂
Want to explore CBG products? Get your medical marijuana card today.
Get Your CardRelated Cannabinoids
Medical Disclaimer
This content is for educational purposes only and is not medical advice. Consult a healthcare provider before using cannabis products.
Individual Variation
Cannabis affects everyone differently based on genetics, tolerance, and other factors. What works for one person may not work for another.
Start Low, Go Slow
Always begin with the lowest effective dose and increase gradually to minimize risk of adverse effects.