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CBDA
Cannabidiolic Acid
Pronounced: see-bee-dee-AY
CBDA (Cannabidiolic Acid) is a non-psychoactive major cannabinoid. Learn about CBDA, the raw precursor to CBD. Discover why research shows it may be more potent than CBD for nausea and inflammation..
Boiling Point
248°F (120°C) - converts to CBD
Formula
C₂₂H₃₀O₄
Legal Status
Legal federally when derived from hemp
What is CBDA?
CBDA is the raw, acidic precursor to CBD found in fresh hemp and cannabis plants. Like THCA, it's converted to CBD through decarboxylation (heat). Recent research suggests CBDA may be even more potent than CBD for certain applications, particularly nausea.
How CBDA Works
CBDA shows high affinity for serotonin 5-HT1A receptors—up to 100x greater than CBD in some studies. This may explain its potent anti-nausea effects. It also inhibits COX-2 enzymes (similar to NSAIDs) and may work synergistically with CBD.
Researched Effects
Anti-nausea
Moderate EvidenceMore potent than CBD or THC for nausea in animal studies.
✓ Compliant Language
Research shows potent anti-nausea activity
✗ Avoid Saying
Cures nausea
Sources
Anti-inflammatory
Moderate EvidenceInhibits COX-2 enzyme similar to NSAIDs.
✓ Compliant Language
Shows anti-inflammatory mechanisms similar to NSAIDs
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Replaces anti-inflammatory medication
Sources
Anxiety Relief
Emerging ResearchHigh 5-HT1A affinity suggests potential anxiolytic effects.
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May support calm through serotonin pathways
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Treats anxiety
Sources
Medical Applications
Chemotherapy-induced Nausea
Moderate EvidenceAnimal studies show greater efficacy than ondansetron at certain doses.
Dosing Guidance
CBDA appears effective at lower doses than CBD. Products typically contain 5-25mg. Must be kept cold to prevent conversion to CBD.
Safety Information
CBDA is non-psychoactive and appears well-tolerated. Unstable molecule that degrades with heat and light—requires proper storage.
Potential Side Effects
- Limited data available
- Generally well-tolerated
- May cause digestive upset in some
Drug Interactions
May inhibit CYP450 enzymes similarly to CBD. Consult physician if taking other medications.
Scientific References
Bolognini D, et al. • British Journal of Pharmacology (2013)
PubMed ID: 23647169
Found CBDA more potent than CBD for nausea via 5-HT1A.
Takeda S, et al. • Drug Metabolism and Disposition (2008)
PubMed ID: 18556441
Demonstrated COX-2 inhibition mechanism.
Rock EM, et al. • Psychopharmacology (2012)
PubMed ID: 22531041
Found high serotonin receptor affinity.
Frequently Asked Questions
What is CBDA?
CBDA (cannabidiolic acid) is the raw, acidic form of CBD found in fresh cannabis and hemp. It converts to CBD when heated through decarboxylation.
Is CBDA better than CBD?
For some applications, possibly. Research shows CBDA may be more potent than CBD for nausea and has higher serotonin receptor affinity. However, CBDA is less stable and requires careful storage.
How do I use CBDA?
CBDA is found in raw hemp products, cold-processed tinctures, and some specially formulated products. It must be kept cold to prevent conversion to CBD.
Quick Facts
- Full Name
- Cannabidiolic Acid
- Category
- major Cannabinoid
- Psychoactive
- No
- Boiling Point
- 248°F (120°C) - converts to CBD
- Formula
- C₂₂H₃₀O₄
Want to explore CBDA-rich products with a doctor?
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Medical Disclaimer
This content is for educational purposes only and is not medical advice. Consult a healthcare provider before using cannabis products.
Individual Variation
Cannabis affects everyone differently based on genetics, tolerance, and other factors. What works for one person may not work for another.
Start Low, Go Slow
Always begin with the lowest effective dose and increase gradually to minimize risk of adverse effects.