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CBC
Cannabichromene
Pronounced: see-bee-SEE
CBC (Cannabichromene) is a non-psychoactive minor cannabinoid. Learn about CBC (cannabichromene), one of the major cannabinoids. Discover its unique properties, entourage effect contributions, and emerging research..
Boiling Point
428°F (220°C)
Formula
C₂₁H₃₀O₂
Legal Status
Legal federally when derived from hemp
What is CBC?
CBC (cannabichromene) is one of the "big six" cannabinoids, discovered in 1966. It's typically the third most abundant cannabinoid in cannabis and doesn't bind strongly to CB1 receptors, making it non-psychoactive. However, CBC acts as a selective CB2 receptor agonist. Recent research has shown anticonvulsant properties in Dravet syndrome models.
How CBC Works
CBC has low affinity for CB1 receptors but acts as a selective CB2 receptor agonist, producing hyperpolarization that can be blocked by the AM630 antagonist. It also interacts with TRP channels (TRPA1, TRPV1-4) involved in pain and inflammation. CBC may enhance the effects of other cannabinoids through the entourage effect.
Researched Effects
Anti-inflammatory
Moderate EvidenceCBC reduced inflammation comparable to phenylbutazone in rodent models.
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Research demonstrates anti-inflammatory properties
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Treats inflammation
Antidepressant
Emerging ResearchCBC showed significant antidepressant-like effects at 20 mg/kg in mouse behavioral tests.
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Animal studies suggest mood-supporting properties
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Treats depression
Sources
Anticonvulsant
Emerging ResearchCBC showed anticonvulsant properties in Dravet syndrome mouse model.
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Being researched for anticonvulsant potential
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Treats seizures or epilepsy
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CB2 Activation
Moderate EvidenceActs as a selective CB2 receptor agonist, which may explain anti-inflammatory effects.
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Research shows CB2 receptor activity
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Activates the endocannabinoid system therapeutically
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Dosing Guidance
Limited human dosing data. CBC is typically found in combination products rather than isolated. Part of full-spectrum hemp extracts.
Safety Information
CBC appears well-tolerated. Non-psychoactive. Limited safety data as a standalone compound.
Potential Side Effects
- Limited data available
- Generally considered well-tolerated
Drug Interactions
Not well-studied. Consult physician if taking other medications.
Scientific References
Tubaro A, et al. • Fitoterapia (2010)
PubMed ID: 20398753
CBC reduced inflammation comparable to phenylbutazone in rodent models.
El-Alfy AT, et al. • Pharmacology Biochemistry and Behavior (2010)
PubMed ID: 20332000
CBC showed significant antidepressant-like effects at 20 mg/kg in mouse forced swim and tail suspension tests.
Anderson LL, et al. • ACS Chemical Neuroscience (2021)
PubMed ID: 33356142
CBC and related phytocannabinoids showed anticonvulsant properties in Dravet syndrome mouse model.
Udoh M, et al. • Cannabis and Cannabinoid Research (2019)
PubMed ID: 31368508
CBC activates CB2 receptors producing hyperpolarization blocked by AM630 antagonist.
Vrana KE, et al. • Cannabis and Cannabinoid Research (2024)
Comprehensive review of CBC pharmacology and therapeutic potential.
Maione S, et al. • British Journal of Pharmacology (2011)
PubMed ID: 21449980
Found synergistic effects with other cannabinoids.
Frequently Asked Questions
What is CBC?
CBC (cannabichromene) is typically the third most abundant cannabinoid in cannabis. It's non-psychoactive and may contribute to the entourage effect in full-spectrum products.
Does CBC get you high?
No. CBC doesn't bind effectively to CB1 receptors and produces no psychoactive effects.
What is CBC used for?
CBC is being researched for anti-inflammatory and mood-supporting properties. It's typically consumed as part of full-spectrum hemp products rather than in isolation.
Quick Facts
- Full Name
- Cannabichromene
- Category
- minor Cannabinoid
- Psychoactive
- No
- Boiling Point
- 428°F (220°C)
- Formula
- C₂₁H₃₀O₂
Want to explore CBC-rich products with a doctor?
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Medical Disclaimer
This content is for educational purposes only and is not medical advice. Consult a healthcare provider before using cannabis products.
Individual Variation
Cannabis affects everyone differently based on genetics, tolerance, and other factors. What works for one person may not work for another.
Start Low, Go Slow
Always begin with the lowest effective dose and increase gradually to minimize risk of adverse effects.