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Pennsylvania Medical Marijuana Qualifying Conditions

Pennsylvania's medical marijuana program recognizes 24 serious medical conditions under 35 P.S. ss 10231.103, including cancer, PTSD, opioid use disorder, anxiety disorders, severe chronic or intractable pain, autism, Tourette syndrome, multiple sclerosis, Crohn's disease, glaucoma, epilepsy, and sickle cell anemia. Pennsylvania is one of the few states that explicitly lists OUD and anxiety as qualifying conditions, with the Medical Marijuana Advisory Board reviewing new petitions on a two-year cycle.

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By Dr. Kevin Kargman, DOLicensed PA Physician #OS023291

Audited: January 1, 2026

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Dr. Rajashree Kantha

Dr. Rajashree Kantha, MD

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Pennsylvania Qualifying Conditions: Detailed Guide

About the Qualifying Medical Conditions

Below is information about each qualifying condition and the research that informed Pennsylvania's decision to include it in the state program per Act 16 of 2016.

Severe Chronic or Intractable Pain

Chronic pain is an approved qualifying condition under Pennsylvania's medical marijuana program per Act 16 of 2016. Pennsylvania included this condition based on systematic reviews examining cannabinoid use among patients with chronic pain conditions.

Anxiety Disorders

Anxiety disorders are approved qualifying conditions under Pennsylvania's medical marijuana program per Act 16 of 2016. Pennsylvania included this condition based on research examining cannabinoid use in patients with anxiety disorders.

Cancer

Cancer is an approved qualifying condition under Pennsylvania's medical marijuana program per Act 16 of 2016. Pennsylvania included this condition based on research examining cannabinoid use among cancer patients experiencing treatment-related symptoms.

Epilepsy and Intractable Seizures

Epilepsy and intractable seizures are approved qualifying conditions under Pennsylvania's medical marijuana program per Act 16 of 2016. Pennsylvania included these conditions based on clinical trial research examining CBD in patients with treatment-resistant epilepsy.

Autism

Autism is an approved qualifying condition under Pennsylvania's medical marijuana program per Act 16 of 2016. Pennsylvania included this condition based on research examining cannabis use among patients with autism spectrum disorder.

PTSD

PTSD is an approved qualifying condition under Pennsylvania's medical marijuana program per Act 16 of 2016. Pennsylvania included this condition based on research examining cannabinoid use among patients with PTSD.

Opioid Use Disorder

Opioid Use Disorder is an approved qualifying condition under Pennsylvania's medical marijuana program per Act 16 of 2016. Pennsylvania included this condition based on research examining cannabis as a potential harm reduction strategy.

Multiple Sclerosis

MS is an approved qualifying condition under Pennsylvania's medical marijuana program per Act 16 of 2016. Pennsylvania included this condition based on clinical research examining cannabinoid use in patients with MS-related spasticity.

Parkinson's Disease

Parkinson's Disease is an approved qualifying condition under Pennsylvania's medical marijuana program per Act 16 of 2016. Pennsylvania included this condition based on research examining cannabinoid use among Parkinson's patients.

Crohn's Disease and IBD

Crohn's Disease and IBD are approved qualifying conditions under Pennsylvania's medical marijuana program per Act 16 of 2016. Pennsylvania included these conditions based on clinical research examining cannabis use in IBD patients.

Chronic Hepatitis C

Chronic Hepatitis C is an approved qualifying condition under Pennsylvania's medical marijuana program per Act 16 of 2016. Pennsylvania included this condition based on research examining cannabis use among patients undergoing antiviral treatment.

ALS

ALS is an approved qualifying condition under Pennsylvania's medical marijuana program per Act 16 of 2016. Pennsylvania included this condition based on research surveying ALS patients about symptom management.

Tourette Syndrome

Tourette Syndrome is an approved qualifying condition under Pennsylvania's medical marijuana program per Act 16 of 2016. Pennsylvania included this condition based on research examining THC use in patients with Tourette's.

Huntington's Disease

Huntington's Disease is an approved qualifying condition under Pennsylvania's medical marijuana program per Act 16 of 2016 as determined by the Pennsylvania Department of Health.

HIV/AIDS

HIV/AIDS is an approved qualifying condition under Pennsylvania's medical marijuana program per Act 16 of 2016. Pennsylvania included this condition based on research examining cannabinoid use among HIV/AIDS patients.

Glaucoma

Glaucoma is an approved qualifying condition under Pennsylvania's medical marijuana program per Act 16 of 2016. Pennsylvania included this condition based on early research examining the relationship between cannabinoids and intraocular pressure.

Sickle Cell Anemia

Sickle Cell Anemia is an approved qualifying condition under Pennsylvania's medical marijuana program per Act 16 of 2016. Pennsylvania included this condition based on research examining cannabis use among sickle cell patients.

Other Conditions

Neuropathies, Neurodegenerative Diseases, Dyskinetic and Spastic Movement Disorders, Damage to the Nervous Tissue of the Central Nervous System, and Terminal Illness are approved qualifying conditions under Pennsylvania's medical marijuana program per Act 16 of 2016 as determined by the Pennsylvania Department of Health.

Medical Disclaimer

This page provides information about Pennsylvania's qualifying conditions for medical cannabis per Act 16 of 2016. The inclusion of a condition in Pennsylvania's program does not constitute medical advice or a guarantee of therapeutic benefit. Individual results vary. Potential side effects may include dizziness, sedation, and cognitive changes. Always consult a healthcare provider before starting treatment.

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FAQ

Common Questions About Pennsylvania Qualifying Conditions

What conditions qualify for a Pennsylvania medical marijuana card?

Pennsylvania's Medical Marijuana Program under 35 P.S. ss 10231.103 recognizes 24 enumerated 'serious medical conditions,' including cancer, PTSD, opioid use disorder (Pennsylvania is one of few states that explicitly lists OUD), severe chronic or intractable pain, autism, anxiety disorders, Tourette syndrome, Parkinson's disease, multiple sclerosis, Crohn's disease, glaucoma, HIV/AIDS, sickle cell anemia, terminal illness, neurodegenerative diseases, neuropathies, dyskinetic and spastic movement disorders, epilepsy, IBD, intractable seizures, ALS, damage to the nervous tissue of the spinal cord, severe sickle cell anemia, and CRPS.

Does anxiety qualify for a Pennsylvania medical marijuana card?

Yes. Anxiety disorders are an enumerated serious medical condition under 35 P.S. ss 10231.103 (added by the PA Medical Marijuana Advisory Board in 2019). A licensed PA-registered practitioner can certify a patient whose primary diagnosis is anxiety. Documentation from a primary care physician or mental-health provider supports certification.

Does opioid use disorder qualify for a Pennsylvania medical card?

Yes. Pennsylvania is one of the few states that explicitly lists 'opioid use disorder for which conventional therapeutic interventions are contraindicated or ineffective, or for which adjunctive therapy is indicated in combination with primary therapeutic interventions' as a serious medical condition under 35 P.S. ss 10231.103. PA-registered practitioners can certify OUD patients who meet the statutory adjunctive-or-alternative criterion.

Does chronic pain qualify in Pennsylvania?

Yes, but with a statutory threshold. 35 P.S. ss 10231.103 covers 'severe chronic or intractable pain of neuropathic origin or severe chronic or intractable pain.' Acute pain or routine post-operative pain does not meet the standard; the pain must be either severe and chronic OR severe and intractable, with documentation that conventional treatment has failed or is contraindicated.

Does autism qualify for a Pennsylvania medical marijuana card?

Yes. Autism is an enumerated serious medical condition under 35 P.S. ss 10231.103. There is no age restriction in the statute; pediatric autism patients require parent or legal-guardian consent and registration as a caregiver. A clinical autism diagnosis from a developmental pediatrician, psychiatrist, or psychologist supports certification.

Can the Pennsylvania program add new qualifying conditions?

Yes. The Pennsylvania Medical Marijuana Advisory Board, established under 35 P.S. ss 10231.1201, may review and recommend new serious medical conditions to the Secretary of Health on a 2-year review cycle. The Board's 2019 expansion added anxiety disorders, Tourette syndrome, and others; new petitions can be submitted through the PA DOH Medical Marijuana Program portal.

What documentation do I need to certify a Pennsylvania qualifying condition?

Pennsylvania-registered practitioners need medical records that confirm your diagnosis of one of the 24 listed serious medical conditions. Acceptable records include notes from a primary care physician or specialist, hospital discharge summaries, imaging or lab reports, pharmacy records, and VA records. MMJ.com's PA-licensed practitioners review uploaded records before issuing the certification submitted to the PA Patient and Caregiver Registry.

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Medically reviewed by: Dr. Kevin Kargman, DO·Pennsylvania License #OS023291·NPI 1407810302

Editorial oversight by: John Progar, CEO & FounderLast Verified: May 2026

Last Updated: December 15, 2024